Preliminary findings are presented from a prospective, longitudinal, multicentre MRI biomarker study of patients presenting with interstitial lung disease (ILD) including drug induced ILD, hypersensitivity pneumonitis, idiopathic pulmonary fibrosis and connective tissue disease ILD. At the time of writing, 27 patients have undergone baseline hyperpolarised xenon-129 (129Xe) MR spectroscopy (MRS) and 129Xe diffusion-weighted MRI. Our findings suggest significant differences in mean 129Xe apparent diffusion coefficient between the ILD subtypes at baseline but no significant differences in the red blood cell / tissue plasma ratio from dissolved 129Xe MRS. We also demonstrate correlation between pulmonary function tests and 129Xe MRI measures.
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