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Abstract #0006

Comparison of Phase-Resolved Functional Lung (PREFUL) MRI and Hyperpolarized 129Xe MRI in Pediatric Cystic Fibrosis

Marcus J. Couch1,2, Jonathan H. Rayment3, Robert Grimm4, Andreas Voskrebenzev5,6, Jens Vogel-Claussen5,6, Felix Ratjen1,7, and Giles Santyr1,2

1Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Division of Respiratory Medicine, British Columbia Children’s Hospital, Vancouver, BC, Canada, 4MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany, 5Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 6Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany, 7Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada

Hyperpolarized 129Xe MRI provides robust measurements of ventilatory function through the measurement of the ventilation defect percent (VDP). Recent progress in 1H-based free-breathing techniques (phase-resolved functional lung; PREFUL) allows for the calculation of fractional ventilation maps, which can be similarly processed to calculate VDP. While hyperpolarized 129Xe is an established research technique, PREFUL MRI is simple to implement on any MRI scanner and therefore has good potential for use in future clinical trials in cystic fibrosis (CF). In this study, VDP measurements performed using hyperpolarized 129Xe and PREFUL MRI were compared and correlated with pulmonary function tests in pediatric CF.

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