Abstract #0006

Comparison of Phase-Resolved Functional Lung (PREFUL) MRI and Hyperpolarized 129Xe MRI in Pediatric Cystic Fibrosis

Marcus J. Couch^1,2, Jonathan H. Rayment³, Robert Grimm⁴, Andreas Voskrebenzev^5,6, Jens Vogel-Claussen^5,6, Felix Ratjen^1,7, and Giles Santyr^1,2

¹Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Division of Respiratory Medicine, British Columbia Children’s Hospital, Vancouver, BC, Canada, ⁴MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany, ⁵Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ⁶Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany, ⁷Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada

Hyperpolarized ¹²⁹Xe MRI provides robust measurements of ventilatory function through the measurement of the ventilation defect percent (VDP). Recent progress in ¹H-based free-breathing techniques (phase-resolved functional lung; PREFUL) allows for the calculation of fractional ventilation maps, which can be similarly processed to calculate VDP. While hyperpolarized ¹²⁹Xe is an established research technique, PREFUL MRI is simple to implement on any MRI scanner and therefore has good potential for use in future clinical trials in cystic fibrosis (CF). In this study, VDP measurements performed using hyperpolarized ¹²⁹Xe and PREFUL MRI were compared and correlated with pulmonary function tests in pediatric CF.

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