Meeting Banner
Abstract #0007

Differences Between 3He and 129Xe Ventilation Heterogeneity Explained Using Oscillometry

Rachel L Eddy1,2, Andrew Westcott1,2, Geoffrey N Maksym3, David G McCormack4, and Grace Parraga1,2,3,4

1Robarts Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3School of Biomedical Engineering, Dalhousie University, Halifax, NS, Canada, 4Division of Respirology, Department of Medicine, Western University, London, ON, Canada

129Xe MRI ventilation defects were previously shown to be greater and more numerous than 3He MRI ventilation defects in patients with chronic obstructive pulmonary disease (COPD) and asthma, however the underlying biomechanical explanation for these differences has not been determined. Here we evaluated the relationships of 3He and 129Xe MRI ventilation defect percent (VDP) with oscillometry measurements acquired in patients to better understand the lung biomechanical constraints that lead to such differences. 129Xe VDP was significantly related to total respiratory-system resistance whereas 3He was not which may suggest increased sensitivity of 129Xe to resistance throughout the entire airway tree.

This abstract and the presentation materials are available to members only; a login is required.

Join Here