Abstract #0007

Differences Between 3He and 129Xe Ventilation Heterogeneity Explained Using Oscillometry

Rachel L Eddy^1,2, Andrew Westcott^1,2, Geoffrey N Maksym³, David G McCormack⁴, and Grace Parraga^1,2,3,4

¹Robarts Research Institute, London, ON, Canada, ²Department of Medical Biophysics, Western University, London, ON, Canada, ³School of Biomedical Engineering, Dalhousie University, Halifax, NS, Canada, ⁴Division of Respirology, Department of Medicine, Western University, London, ON, Canada

¹²⁹Xe MRI ventilation defects were previously shown to be greater and more numerous than ³He MRI ventilation defects in patients with chronic obstructive pulmonary disease (COPD) and asthma, however the underlying biomechanical explanation for these differences has not been determined. Here we evaluated the relationships of ³He and ¹²⁹Xe MRI ventilation defect percent (VDP) with oscillometry measurements acquired in patients to better understand the lung biomechanical constraints that lead to such differences. ¹²⁹Xe VDP was significantly related to total respiratory-system resistance whereas ³He was not which may suggest increased sensitivity of ¹²⁹Xe to resistance throughout the entire airway tree.

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