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Abstract #0205

Ultra high field BOLD measurements combined with simultaneous determination of blood oxygenation and blood volume by optical imaging

Rebekka Bernard1, Klaus Scheffler1,2, and Rolf Pohmann1

1Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany

To disentangle the different parameters contributing to the BOLD effect, a combined setup for intrinsic optical imaging and ultra high field fMRI in rats was designed, using a magnetic field compatible, high sensitivity camera and professional optical components. By illumination of the brain surface with light in four different wavelengths, oxygenation and CBV was observed concurrently with fMRI during forepaw stimulation. Simultaneous measurement of those parameters can help to better understand the BOLD effect and to add additional value to both optical imaging and fMRI experiments.

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