Pancreatic ductal adenocarcinoma (PDAC) is one of the most-common malignant tumors and has poor outcomes. With increasing size, the mass causes obstruction of the main pancreatic duct which results in chronic pancreatitis of the upstream pancreas (towards the tail). However, the downstream pancreas (towards the head) does not have these changes. In this study, we quantitatively measured multiple MR parameters (T1, T2, and ADC) of PDAC, upstream, and downstream pancreas along with normal pancreas in healthy volunteers and found these values can be used to differentiate these tissue types. The combination of the three parameters improves overall accuracy in differentiating PDAC with upstream pancreas, downstream pancreas, and normal pancreas over single parameter.