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Abstract #0587

Non-Contrast Multiparametric Mapping for Pancreatic Ductal Adenocarcinoma Cancer (PDAC) Tissue Characterization

Lixia Wang1,2, Yibin Xie2, Srinivas Gaddam3, Nan Wang2, Zixin Deng2, Zhengwei Zhou2, Wensha Yang3, Zhaoyang Fan2, Tao Jiang1, Simon Lo3, Andrew Hendifar3, Stephen Pandol3, and Debiao Li2

1Radiological Department, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Cedars-Sinai Medical Center, Los Angeles, CA, United States

Pancreatic ductal adenocarcinoma (PDAC) is one of the most-common malignant tumors and has poor outcomes. With increasing size, the mass causes obstruction of the main pancreatic duct which results in chronic pancreatitis of the upstream pancreas (towards the tail). However, the downstream pancreas (towards the head) does not have these changes. In this study, we quantitatively measured multiple MR parameters (T1, T2, and ADC) of PDAC, upstream, and downstream pancreas along with normal pancreas in healthy volunteers and found these values can be used to differentiate these tissue types. The combination of the three parameters improves overall accuracy in differentiating PDAC with upstream pancreas, downstream pancreas, and normal pancreas over single parameter.

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