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Abstract #0588

Assessment of Tumor Hypoxia response to sorafenib in Rabbit VX2 Liver Tumor xenografts by Tissue Oxygen Level Dependent MR imaging

Shuping Qin1, Xinming Li1, Zhendong Qi1, Wen Liang1, Yingjie Mei2, Jingjing Huang1, and Xianyue Quan1

1Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, 2MR Clinical Science, Philips Healthcare, Guangzhou, China

Developing non-invasive methods that assess drug resistance, which causes tumor hypoxia, is a research hotspot. We applied tissue oxygen level dependent (TOLD) MRI to investigate the changes in tumor oxygen inhalation of rabbit liver VX2 tumor xenografts before and sorafenib treatment.

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