Abstract #0588

Assessment of Tumor Hypoxia response to sorafenib in Rabbit VX2 Liver Tumor xenografts by Tissue Oxygen Level Dependent MR imaging

Shuping Qin¹, Xinming Li¹, Zhendong Qi¹, Wen Liang¹, Yingjie Mei², Jingjing Huang¹, and Xianyue Quan¹

¹Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China, ²MR Clinical Science, Philips Healthcare, Guangzhou, China

Developing non-invasive methods that assess drug resistance, which causes tumor hypoxia, is a research hotspot. We applied tissue oxygen level dependent (TOLD) MRI to investigate the changes in tumor oxygen inhalation of rabbit liver VX2 tumor xenografts before and sorafenib treatment.

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