Abstract #0589

Improvement and systematic analysis of the selective multiple quantum coherence 1H MRS lactate imaging pulse sequence for application to brain tumor and lymphoma patients

Seung-Cheol Lee¹, Hari Hariharan¹, Gabor Mizsei¹, Sanjeev Chawla¹, Kavindra Nath¹, Fernando Arias-Mendoza¹, Mark Elliot¹, Drew Torigian¹, Jakub Svoboda², Sunita Nasta², Stephen Schuster², Ravinder Reddy¹, and Jerry Glickson¹

¹Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ²Division of Hematology Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

We have tested our revised Sel-MQC-CSI sequence for dependence of Lac/H₂O on the B0 and B1 field inhomogeneity. The immunity of the Lac/H₂O from our sequence on the above factors was demonstrated. We have improved lipid suppression from previously reported 100-fold to 22,000-fold while not losing the lactate signal. The revised sequence was applied to a glioma patient and a normal volunteer with a lactate phantom seated near the typical lymphoma occurring region of the body. In both human studies, satisfactory performance of the sequence was demonstrated.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.