Abstract #0589

Improvement and systematic analysis of the selective multiple quantum coherence 1H MRS lactate imaging pulse sequence for application to brain tumor and lymphoma patients

Seung-Cheol Lee¹, Hari Hariharan¹, Gabor Mizsei¹, Sanjeev Chawla¹, Kavindra Nath¹, Fernando Arias-Mendoza¹, Mark Elliot¹, Drew Torigian¹, Jakub Svoboda², Sunita Nasta², Stephen Schuster², Ravinder Reddy¹, and Jerry Glickson¹

¹Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ²Division of Hematology Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

We have tested our revised Sel-MQC-CSI sequence for dependence of Lac/H₂O on the B0 and B1 field inhomogeneity. The immunity of the Lac/H₂O from our sequence on the above factors was demonstrated. We have improved lipid suppression from previously reported 100-fold to 22,000-fold while not losing the lactate signal. The revised sequence was applied to a glioma patient and a normal volunteer with a lactate phantom seated near the typical lymphoma occurring region of the body. In both human studies, satisfactory performance of the sequence was demonstrated.

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