Abstract #0590

Investigating the relation between amide signal and pH in breast cancer using CEST-MRI and 31P MRSI at 7T.

Erwin Krikken¹, Vitaliy Khlebnikov¹, Wybe J.M. van der Kemp¹, Hanneke W.M. van Laarhoven², Peter R. Luijten¹, Maurice A.A.J. van den Bosch¹, Dennis W.J. Klomp¹, and Jannie P. Wijnen¹

¹Radiology, University Medical Centre Utrecht, Utrecht, Netherlands, ²Oncology, Amsterdam Medical Centre, Amsterdam, Netherlands

In this study, we combine CEST-MRI and ³¹P-MRSI measurements, to better comprehend the underlying mechanisms of the measured changes in APT signal by relating it to the pH_i. CEST-MRI and ³¹P-MRSI were acquired in breast cancer patients receiving neoadjuvant chemotherapy (NAC) treatment before and after the first cycle of NAC at 7T. We found a linear correlation between APT-CEST and pH and a linear correlation between PE/Pi and the pH in the tumor of breast cancer patients before the start of NAC treatment. We hypothesized that an increased pH results in an increased APT signal, yet we found the opposite. As APT mainly depends on mobile amide proton concentration and the exchange rate, this data suggest that the main contributor to the APT signal is the concentration of mobile amide protons.

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