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Abstract #0997

High Resolution Diffusion MRI of the Hippocampus Reveals Heterogenous Development across the Head, Body, and Tail Through Childhood and Adolescence

Kevin Grant Solar1, Sarah Treit1, Emily Stolz1, and Christian Beaulieu1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada

High resolution diffusion tensor imaging reveals regional-specificity in microstructural development of the healthy human hippocampus over 6-20 years. The whole structure, head, body, and tail were visualized and segmented directly on mean diffusion-weighted images. Whole-structure analyses showed age-related higher FA and lower MD, and substructure analysis revealed that these associations were strongest in the head – a finding corroborated by prior shape analyses showing greater expansion in the hippocampal head during development. This regional-specificity may reflect hippocampal neurogenesis and myelination in coherence with the high concentration of connections that form at the head from childhood into adulthood.

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