We present data from a multi-center trial involving patients with advanced CKD (stage 3B & 4) with multiple etiologies. BOLD and Diffusion MRI data was acquired at baseline and repeated 1 year later. Renal function was monitored on a quarterly basis to evaluate progression. Our data show for the first time a strong association of ADC with annual loss of renal function. Further ADC values showed differences when individuals were stratified by diabetes and progression status. BOLD MRI did not demonstrate similar association.