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Abstract #1201

Lower ADC Values are Associated with Annual Loss of Renal Function in Individuals with Advanced CKD

Anand Srivatsava1, Wei Li2, Tamara Isakova1, Stuart Sprague2, COMBINE Investigators3, and Pottumarthi V Prasad2

1Northwestern University, Chicago, IL, United States, 2NorthShore University HealthSystem, Evanston, IL, United States, 3NIDDK, Bethesda, MD, United States

We present data from a multi-center trial involving patients with advanced CKD (stage 3B & 4) with multiple etiologies. BOLD and Diffusion MRI data was acquired at baseline and repeated 1 year later. Renal function was monitored on a quarterly basis to evaluate progression. Our data show for the first time a strong association of ADC with annual loss of renal function. Further ADC values showed differences when individuals were stratified by diabetes and progression status. BOLD MRI did not demonstrate similar association.

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