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Abstract #1202

Unbiased MRI Assessment of Renal Tubular Volume Fraction with Data-Driven IVIM

Joao Periquito1, Min-Chi Ku1, Kathleen Cantow2, Erdmann Seeliger2, Bert Flemming2, Thomas Gladytz3, Dirk Grosenick3, Thoralf Niendorf1,4, and Andreas Pohlmann1

1Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Institute for Vegetative Physiology, Charité – Universitaetsmedizin Berlin, Berlin, Germany, 3Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, 4Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

T2* mapping does not fully represent renal tissue oxygenation. Tubular volume fraction changes should be considered to correct T2*. Diffusion weighted imaging provides information about in-vivo evaluation of water mobility which can be linked to three sources: tissue water diffusion, blood flow, and tubular flow. In this work we explore the feasibility of assessing tubular volume fraction changes using the non-negative least squares (NNLS) approach that is data-driven and requires no a priori knowledge

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