Abstract #1202

Unbiased MRI Assessment of Renal Tubular Volume Fraction with Data-Driven IVIM

Joao Periquito¹, Min-Chi Ku¹, Kathleen Cantow², Erdmann Seeliger², Bert Flemming², Thomas Gladytz³, Dirk Grosenick³, Thoralf Niendorf^1,4, and Andreas Pohlmann¹

¹Max Delbrueck Center for Molecular Medicine, Berlin, Germany, ²Institute for Vegetative Physiology, Charité – Universitaetsmedizin Berlin, Berlin, Germany, ³Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, ⁴Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

T₂* mapping does not fully represent renal tissue oxygenation. Tubular volume fraction changes should be considered to correct T₂*. Diffusion weighted imaging provides information about in-vivo evaluation of water mobility which can be linked to three sources: tissue water diffusion, blood flow, and tubular flow. In this work we explore the feasibility of assessing tubular volume fraction changes using the non-negative least squares (NNLS) approach that is data-driven and requires no a priori knowledge

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