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Abstract #1203

Fast hybrid IVIM-DK imaging in the kidney

Kao-Lang Liu1, Kuo-How Huang2, Chin-Chen Chang1, and Wen-Chau Wu1,3,4

1Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 2Department of Urology, National Taiwan University Hospital, Taipei, Taiwan, 3Graduate Institute of Medical Device and Imaging, National Taiwan University, Taipei, Taiwan, 4Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan

The application of intravoxel incoherent motion (IVIM) and diffusion kurtosis (DK) MRI has been hindered largely by the long scan time required to sample over multiple b-values and/or diffusion-encoding directions. In this study, a novel method is described to expedite hybrid IVIM-DK imaging in the kidneys. Scan time is reduced by acquiring minimally-required non-zero b-values, while index calculation is made more time-efficient by using closed-form solution to replace nonlinear fitting. Experimental data demonstrated feasibility with b = 0/400/800/1600 s/mm2. Measurement variability was found greater among diffusion-encoding directions than between repeats, suggesting non-trivial structural anisotropy in the kidneys.

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