The purpose of this study is to assess the feasibility of MRI texture analysis as a method of quantifying vertebral subchondral bone (VSB) in early intervertebral disk degeneration (IDD). Sagittal T1WI, T2WI and T2* mapping images of lumbar vertebra were scanned at 3T MRI. Texture parameter values(mean, variance, skewness, correlation and entropy) of VSB (on T1WI) and T2* value of CEP were used for statistical evaluations. It was found that Significant differences in VSB texture parameters (mean ,variance and entropy) and T2* value of CEP were demonstrated between groups at the cephalic and caudal. Accordingly, texture parameter-mean showed significantly higher diagnostic accuracy than other texture parameters (variance and entropy) and T2* value for differentiating early IDD. MRI texture analysis can be used to assess human lumbar early IDD.
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