Abstract #1331

gagCEST effect strongly depends on GAG molecular composition

Emma Olsson¹, Pernilla Peterson¹, André Struglics², Michael Gottschalk³, Patrik Önnerfjord⁴, and Jonas Svensson^1,5

¹Medical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden, ²Orthopaedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden, ³Lund University Bioimaging Center, Lund University, Lund, Sweden, ⁴Rheumatology and Molecular Skeletal Biology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden, ⁵Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden

gagCEST has been suggested as a method for in vivo evaluation of cartilage GAG content. The main type of GAG in cartilage is chondroitin sulfate (CS), most commonly CS-A and CS-C. Validation of gagCEST have mostly been performed using CS-A but the main type in mature human articular cartilage is CS-C. In this study we evaluate the gagCEST effect from GAG in different forms. Our results indicate that mainly CS-A is contributing to gagCEST effect in cartilage, while no or little effect is seen from CS-C. gagCEST may therefore not correctly reflect the GAG content of human articular cartilage.

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