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Abstract #1699

Metabolic biomarkers associated with occurrence of hepatocellular carcinoma in patients with liver cirrhosis: in vivo 1H magnetic resonance spectroscopy

Chung Man Moon1,2, Sang Soo Shin2,3, Yong Yeon Jeong2,4, and Suk Hee Heo2,4

1National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, United States, 2Radiology, Chonnam National University Medical School, Gwangju, Korea, Republic of, 3Radiology, Chonnam National University Hospital, Gwangju, Korea, Republic of, 4Radiology, Chonnam National University Hwasun Hospital, Gwangju, Korea, Republic of

Liver cirrhosis (LC) secondary to chronic hepatitis can lead to serious complications. More severely, liver cirrhotic patients may eventually develop hepatocellular carcinoma (HCC), thus monitoring disease progression is clinically important. The purpose of this study was to investigate the utility of 1H magnetic resonance spectroscopy (1H-MRS) with long echo time to quantify the differences in hepatic metabolites of normal, cirrhotic liver with and without HCC, and HCC. These findings would be helpful for understanding of liver metabolic changes related with developing HCC in the cirrhotic liver.

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