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Abstract #1902

A longitudinal study of lesion evolution in atheroembolic renal disease using BOLD MRI

Hanjing Kong1, Chengyan Wang2, Fei Gao1, Xiaodong Zhang3, Min Yang3, Jue Zhang1, and Xiaoying Wang3

1Peking University, Beijing, China, 2Shanghai Jiao Tong University, Shanghai, China, 3Peking University First Hospital, Beijing, China

Atheroembolic renal disease (AERD) is part of a multisystemic disease caused by showers of cholesterol emboli from the atherosclerotic aorta to many organs and is usually associated with poor renal and patient survival. The specific evolution of renal tissue properties remains unclear because of the lack of sensitive imaging biomarkers to detect subtle AERD lesions. Once the embolus enters the blood circulation, it will cause tissue ischemia, endothelial inflammation and even renal function damage. Therefore, the level of blood oxygen is a perfect pointcut for AERD development. In this study, we aim to use blood oxygenation level dependent (BOLD) MRI to evaluate longitudinal changes in kidney properties before and after AERD appearance.

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