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Abstract #2210

Optimization of Steady-Pulsed Arterial Spin Labeling for Myocardial Perfusion Imaging

Ahsan Javed1, Nam Gyun Lee2, Hung Phi Do3, Nilesh Ghugre4, Graham Wright4, Eric Wong5, and Krishna S Nayak1,2

1Electrical Engineering, University of Southern California, Los Angeles, CA, United States, 2Biomedical Engineering, University of Southen California, Los Angeles, CA, United States, 3Department of Clinical Collaborations, Canon Medical Systems USA, Tustin, CA, United States, 4Sunny Brook Research Institute, University of Toronto, Toronto, ON, Canada, 5Electrical Engineering, University of California Sandiego, Sandiego, CA, United States

Arterial spin labeling (ASL) is an attractive non-contrast option for myocardial perfusion imaging. Steady pulsed labeling has been shown to provide the highest signal efficiency in-vivo. In this work, we determine the flip-angle and imaging interval that provide maximum signal efficiency and temporal SNR using Bloch simulation and experiments in healthy swine. We demonstrate that an imaging FA of 40-50Âșand imaging interval of 1-RR is optimal.

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