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Abstract #2261

Functional MRS of aspartate, glutamate, glutamine and GABA- at 3 Tesla

Andrei Manzhurtsev1,2, Alexey Yakovlev3, Petr Menshchikov1,2,4, Maxim Ublinskiy1,2, Tolib Akhadov2, and Natalia Semenova1,2,4

1Emanuel Institute of Biochemical Physics of RAS, Moscow, Russian Federation, 2Radiology, Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russian Federation, 3Moscow State University, Moscow, Russian Federation, 4Semenov Institute of Chemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation

In this research visual stimulation was used for the first functional MRS of aspartate, TE averaging – for pure glutamate and glutamine, and MEGA-PRESS for GABA- to find activation-induced changes at 3 Tesla. The results (except for glutamine) are in compliance with previously published data for 7T. The parameters behavior might reflect the manifestation of Glu neurotransmitter function predominance and metabolic character of changes in the concentrations of other parameters studied.

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