Abstract #2262

Long-term sensory stimulation causes slow GABA rise after fast glutamate rise: E/I balance monitored by 1H-MRS in awake mice brain

Yuhei Takado¹, Hiroyuki Takuwa¹, Manami Takahashi¹, Masafumi Shimojo¹, Takuya Urushihata¹, Nobuhiro Nitta², Sayaka Shibata², Jamie Near³, Maiko Ono¹, Jun Maeda¹, Naruhiko Sahara¹, Yutaka Tomita⁴, Ichio Aoki², Tetsuya Suhara¹, and Makoto Higuchi¹

¹Department of Functional Brain Imaging Research, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ²Department of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ³Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁴Department of Neurology, Keio University School of Medicine, Tokyo, Japan

To clarify different temporal alterations of Glutamate (Glu) and GABA levels for excitatory/inhibitory (E/I) balance during neural activity in awake healthy mice, we performed ¹H-MRS during whisker stimulation. The short term sensory stimulation increased the level of Glu, then long term stimulation by repeating whisker stimulation increased GABA levels, resulting in an inhibitory dominant E/I ratio. It is conceivable that the decreased E/I ratio may be associated with sensory habituation. Given the significant influence of anesthesia on neural activity, awake ¹H-MRS in mice is valuable for investigating E/I balance in relation to brain function.

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