Abstract #2263

Indirect 1H-[13C] NMR Spectroscopy in Rodent Alzheimer’s Model

Steven Zhang^1,2, Masoumeh Dehghani^2,3, Jim Gourdon⁴, Chathura Kumaragamage⁵, and Jamie Near^2,3

¹Integrative Program in Neuroscience, McGill University, Montreal, QC, Canada, ²Brain Imaging Center, Douglas Mental Health Institute, Montreal, QC, Canada, ³Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁴Comparative Medicine & Animal Resources Centre, McGill University, Montreal, QC, Canada, ⁵Yale University, New Haven, CT, United States

Alzheimer’s disease (AD) is a neurodegenerative disorder commonly associated with neuronal metabolic deficits. In this study, we employ an indirect ¹H-[¹³C] MRS approach to investigate changes in glucose metabolism between wild type and transgenic Alzheimer rats. This method can be used to follow the labeling of downstream metabolites after [1-6,¹³C₂] glucose infusion and allows for quantitative measurements of the rate of ¹³C-label transfer from glucose into glutamate and glutamine in the brain. Preliminary comparison of ¹³C fractional enrichment time courses suggest that transgenic rats exhibit slower ¹³C metabolite labeling, indicative of a lowered glucose metabolic rate in AD pathology.

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