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Abstract #2523

Using dynamic sodium imaging to assess furosemide action in the porcine kidney

James T Grist1, Esben Søvsø Szocska Hansen2, Rasmus Stilling Tougaard2, Frank Riemer3, Christoffer Laustsen4, and Ferdia A. Gallagher5

1University of Birmingham, Birmingham, United Kingdom, 2Aarhus Unviersity, Aarhus, Denmark, 3Unviersity of Cambridge, Cambridge, United Kingdom, 4University of Aarhus, Aarhus, Denmark, 5University of Cambridge, Cambridge, United Kingdom

The ability to image sodium is believed to be a powerful tool to understand physiological processes, however have yet to be effectivity translated to clinical realistic usage. Through the use of an efficient k-space trajectory (3D cones) we have undertaken dynamic imaging of the renal sodium distribution pre and post- a furosemide injection. This work shows a decrease in the cortico-medullary sodium gradient over time, as well as being the first renal study on a clinical system with dynamic sodium imaging.

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