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Abstract #2524

Cerebellar GABA+/Glx ratios in essential tremor patients are correlated with tremor severity

Sofie Tapper1,2, Nathanael Göransson3, Peter Lundberg1,2, Peter Zsigmond4, and Anders Tisell1,2

1Department of Radiation Physics, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Biomedical Engineering and Department of Neurosurgery, Linköping University, Linköping, Sweden, 4Department of Clinical and Experimental Medicine, and Department of Neurosurgery, Linköping University, Linköping, Sweden

The aims of this study were to investigate whether GABA+ and Glx concentrations, and the relation between them, were altered in patients with severe essential tremor (ET) compared to healthy controls, and to investigate if the GABA and Glx concentrations were associated with the tremor severity. We observed an increasing GABA+/Glx ratio with tremor severity in the ET patients. Our conclusion was that this increasing cerebellar GABA+/Glx ratio mainly was driven by the decrease in Glx rather than an increase in GABA+, which suggests that an increasing tremor severity is partly due to a disturbance in the Glx concentration.

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