Abstract #2525

The Neurotransmitter NAAG in Different Phases of Relapsing-Remitting Multiple Sclerosis Patients

Patrik O Wyss^1,2,3, Nikolai Pfender⁴, Roland Martin⁴, Andreas Lutterotti⁴, and Anke Henning^2,3

¹Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland, ²Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, ³Max-Planck Institute for Biological Cybernetics, Tuebingen, Germany, ⁴Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital and University Zurich, Zurich, Switzerland

This study explores the alterations of N-Acetyl aspartate (NAA) and the neurotransmitter N-Acetyl aspartyl glutamate (NAAG) in the cerebral normal-appearing white tissue of multiple sclerosis patients with a relapsing-remitting course. A two-dimensional J-resolved single voxel spectroscopy sequence and two-dimensional prior-knowledge fitting is used to disentangle the resonance lines of NAA and NAAG.

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