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Abstract #2526

High intrahepatic lipid content is associated with low choline status in humans-a 1H-MRS study at 3 Tesla

Pandichelvam Veeraiah1,2, Kay H M Roumans2, Joachim E Wildberger1, Patrick Schrauwen2, Lucas Lindeboom1,2, and Vera B Schrauwen-Hinderling1,2

1Department of Radiology, Maastricht University Medical Centre, Mastricht, Netherlands, 2Nutrition and Movement Sciences, NUTRIM school for Nutrition and Translational Research in Metabolism, Maastricht, Netherlands

Non-alcoholic fatty liver (NAFL) has become a major threat to metabolic health. Animal studies have suggested that disturbances in choline metabolism may be linked to the development of NAFL. However, to date, human data on the link of choline and NAFL is scarce. The trimethylammonium (TMA) group of choline can be detected with 1H-MRS at 3.20 ppm. Here, we investigated the relationship between intrahepatic choline levels and hepatic lipid content on healthy overweight/obese subjects using 1H-MRS at 3 Tesla. Our results showed that high hepatic lipid content is associated with low choline content in the liver.

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