4D flow MRI shows great potential in neurovascular disorders such as stenosis, atherosclerotic disease, aneurysms, and vascular malformations. Its widespread application in neurovascular system requires evidence of good test-retest multi-center reproducibility. The purpose of this study is to assess the multi-center reproducibility and test-retest reliability of 4D flow MRI in measurements of cerebral blood flow/velocity in main intracranial vessels. As a result, high multi-center reproducibility and test-retest reliability was shown for 4D flow MRI in the measurements of blood flow and peak velocity of main intracranial vessels for healthy volunteers.
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