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Abstract #2674

Cortical structure mediates the effect of childhood maltreatment on depression relapse during longitudinal follow-up

Harald Kugel1, Nils Opel2, Ronny Redlich2, Katharina Dohm2, Dario Zaremba2, Janik Goltermann2, Jonathan Repple Repple2, Claas Kaehler2,3, Dominik Grotegerd2, Elisabeth J. J. Leehr2, Joscha Böhnlein2, Katharina Förster2, Susanne Meinert2, Verena Enneking2, Lisa Sindermann2, Fanny Dzvonyar2, Daniel Emden2, Ramona Leenings2, Nils Winter2, Tim Hahn2, Walter Heindel1, Ulrike Buhlmann4, Bernhard T. Baune5, Volker Arolt2, and Udo Dannlowski2

1Institute of Clinical Radiology, University of Münster, Münster, Germany, 2Department of Psychiatry, University of Münster, Münster, Germany, 3Department of Mathematics and Computer Science, University of Münster, Münster, Germany, 4Department of Clinical Psychology and Psychotherapy, University of Münster, Münster, Germany, 5Department of Psychiatry, University of Melbourne, Melbourne, Australia

Childhood maltreatment is a strong risk factor for the onset of major depressive disorder (MDD) and associated with unfavorable course of the disease. Both, maltreatment and MDD have been independently associated with structural alterations in partly overlapping brain regions suggesting that brain structural changes could mediate the adverse influence of maltreatment on clinical outcome in MDD. In this study the relationship between childhood trauma, brain structural alterations and adverse disease course was investigated in a longitudinal design. Our results suggest that cortical surface area reductions might mediate the prospective association between early life stress and future depression relapse.

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