Meeting Banner
Abstract #2675

Evidence for an association between low-grade peripheral inflammation and brain structural alterations in major depression

Harald Kugel1, Nils Opel2, Micah Cearns3, Scott Clark3, Catherine Toben3, Dominik Grotegerd2, Walter Heindel1, Anja Teuber4, Heike Minnerup4, Matthias Nauck5, Klaus Berger4, Udo Dannlowski2, and Bernhard T. Baune6

1Institute of Clinical Radiology, University of Münster, Münster, Germany, 2Department of Psychiatry, University of Münster, Münster, Germany, 3Discipline of Psychiatry, University of Adelaide, Adelaide, Australia, 4Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany, 5Institute of Laboratory Medicine, University of Greifswald, Greifswald, Germany, 6Department of Psychiatry, University of Melbourne, Melbourne, Australia

Preliminary research suggests that major depressive disorder (MDD) is associated with structural alterations of brain regions relevant for emotion regulation and associated with low-grade peripheral inflammation as indicated by high sensitive C-reactive protein (hsCRP) serum levels. This association between structural brain alterations and low-grade inflammation as potentially interrelated biological correlates of MDD was investigated. In MDD patients, but not healthy controls, prefrontal gray matter volume reductions were significantly associated with higher hsCRP levels.

This abstract and the presentation materials are available to members only; a login is required.

Join Here