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Abstract #2676

Abnormal functional connectivity of ACC sub-regions in patients with major depressive disorders

Xiaolong Peng1, Xiaoping Wu2, Pan Lin3, Ruxue Gong4, Rui Yang5, and Wenzhen Zhu1

1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Department of Radiology, the Affiliated Xi'an Central Hospital of Xi'an Jiaotong University, Xi'an, China, 3Key Laboratory of Cognitive Science, College of Biomedical Engineering, South-Central University for Nationalities, Wuhan, China, 4Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 5Department of Psychiatry, the Affiliated Xi'an Central Hospital of Xi'an Jiaotong University, Xi'an, China

Major depressive disorder (MDD) is a common mental disorder characterized by cognitive and affective deficits. Prior works indicated that anterior cingulate cortex (ACC) is related to high-level cognitive and emotion process, which is also thought to be pivotal to depression. Here, we examined the resting FC of ACC sub-regions in fist-episode MDD patients. The current results revealed reduced ACC sub-regional FC with IPL and SPL while increased FC was found in dmPFC. Additionally, FC with IPL also negatively correlated with symptom severity (HDRS), indicating that depression may disrupt the normal interactions within the DMN. These findings on alteration of ACC sub-regional FC may contribute to the comprehension in pathophysiology of MDD.

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