Abstract #2676

Abnormal functional connectivity of ACC sub-regions in patients with major depressive disorders

Xiaolong Peng¹, Xiaoping Wu², Pan Lin³, Ruxue Gong⁴, Rui Yang⁵, and Wenzhen Zhu¹

¹Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²Department of Radiology, the Affiliated Xi'an Central Hospital of Xi'an Jiaotong University, Xi'an, China, ³Key Laboratory of Cognitive Science, College of Biomedical Engineering, South-Central University for Nationalities, Wuhan, China, ⁴Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁵Department of Psychiatry, the Affiliated Xi'an Central Hospital of Xi'an Jiaotong University, Xi'an, China

Major depressive disorder (MDD) is a common mental disorder characterized by cognitive and affective deficits. Prior works indicated that anterior cingulate cortex (ACC) is related to high-level cognitive and emotion process, which is also thought to be pivotal to depression. Here, we examined the resting FC of ACC sub-regions in fist-episode MDD patients. The current results revealed reduced ACC sub-regional FC with IPL and SPL while increased FC was found in dmPFC. Additionally, FC with IPL also negatively correlated with symptom severity (HDRS), indicating that depression may disrupt the normal interactions within the DMN. These findings on alteration of ACC sub-regional FC may contribute to the comprehension in pathophysiology of MDD.

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