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Abstract #2677

Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity

Stephanie S. G. Brown1, John W. Rutland1, Gaurav Verma1, Rebecca Feldman1, Judy Alper1, Molly Schneider1, Bradley N. Delman1, James Murrough1, and Priti Balchandani1

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Subcortical volumetric changes in MDD have been purported to underlie the symptoms of MDD, however, the evidence to date remains inconsistent. Here, we investigated the relationship between structural limbic brain measurements and MDD symptomology through high-resolution segmentation of the amygdala and hippocampus. We report the novel finding that MDD severity is consistently negatively associated with amygdala nuclei, linking volumetric reductions with worsening depressive symptoms.

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