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Abstract #2678

Anomalous functional connectivity in subregional amygdala networks in major depressive disorder

Shi Tang1, Hailong Li1, Lu Lu1, Lianqing Zhang1, Xuan Bu1, Xiaoxiao Hu1, Yingxue Gao1, Xinyu Hu1, Yanlin Wang1, Qiyong Gong1, and Xiaoqi Huang1

1Huaxi Magnetic Resonance Research Center (HMRRC), Chengdu, China

The LB, CM, SF and Astr are four main subregions of the amygdala. In this study, we use seed-based functional connectivity method to determine amygdala network dysfunction in MDD. Compared with HC, patients with major depressive disorder showed hypoconncetivity in AStr/LB- OFC circuits, in CM /SF-brainstem/cerebellum circuits and in AStr/CM/SF-thalamus/striatum circuits. These dysfunction in amygdala networks may modulate different emotional and cognitive function in derpession.

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