The LB, CM, SF and Astr are four main subregions of the amygdala. In this study, we use seed-based functional connectivity method to determine amygdala network dysfunction in MDD. Compared with HC, patients with major depressive disorder showed hypoconncetivity in AStr/LB- OFC circuits, in CM /SF-brainstem/cerebellum circuits and in AStr/CM/SF-thalamus/striatum circuits. These dysfunction in amygdala networks may modulate different emotional and cognitive function in derpession.
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