Abstract #2679

Abnormal Blood-Brain Barrier Water Permeability in Major Depressive Disorder

Kenneth Wengler¹, Kwan Chen², Turhan Canli³, Christine DeLorenzo⁴, Mark E Schweitzer², and Xiang He²

¹Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ²Radiology, Stony Brook University, Stony Brook, NY, United States, ³Psychology, Stony Brook University, Stony Brook, NY, United States, ⁴Psychiatry, Stony Brook University, Stony Brook, NY, United States

Blood-brain barrier (BBB) disruption may be the key mechanism leading to neuronal dysfunction and neuroinflammation in major depressive disorder (MDD). Active pathways account for a large portion of trans-membrane water exchange, providing a link between BBB water permeability and metabolism. In this study alterations in BBB water permeability parameters, water extraction fraction (E_w) and water permeability surface area product (PS_w), in patients with MDD were investigated using the recently developed Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) technique. Compared to healthy subjects, MDD patients exhibited significantly lower PS_w and E_w with no differences in cerebral blood flow.

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