For stroke imaging, motion correction and scan time reduction are essential. We optimized the single-shot FLAIR sequence and implemented it into our stroke MR protocol. 48 patients suspected of stroke were retrospectively involved, and board-certified radiologists evaluated the images of our modified-single-shot FLAIR and conventional FLAIR at the terms of degree of motion artifact, image quality, delineation of hyperintense vessel and contribution for diagnosis. Motion artifact was significantly reduced (P < 0.001) and scan time was decreased by 40% in single-shot FLAIR. Hyperintense vessels were equally detected in both the sequences. Radiologists considered modified-single-shot FLAIR more useful for diagnosis.