Abstract #2813

7T MRS of neurometabolites and associations with cognitive deficits in mild cognitive impairment

Georg Oeltzschner^1,2, S. Andrea Wijtenburg³, Mark Mikkelsen^1,2, Richard A. E. Edden^1,2, Peter B. Barker^1,2, Jin Hui Joo⁴, Jeannie-Marie S. Leoutsakos⁴, Laura M. Rowland³, Clifford I. Workman⁴, and Gwenn S. Smith^1,4

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Neuroimaging Research Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States, ⁴Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Mild cognitive impairment (MCI) is associated with increased risk of developing Alzheimer’s Disease (AD). Here, levels of multiple brain metabolites in healthy controls and MCI patients using 7T magnetic resonance spectroscopy in the anterior (ACC) and posterior (PCC) cingulate cortex were studied. MCI patients showed decreased GABA/tCr (ACC, PCC), Glu/tCr (PCC), NAA/tCr (PCC), and increased mI/tCr (ACC). Worse episodic verbal memory performance correlated with lower Glu/tCr (PCC), lower NAA/tCr (PCC), and higher mI/tCr (ACC, PCC). Worse verbal fluency performance correlated with lower GSH/tCr (PCC). In summary, MCI is associated with decreased GABA and glutamate, most consistently in the PCC.

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