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Abstract #2814

Monitoring the neurotransmitter response to hypoglycemia in the prefrontal cortex in diabetes using an advanced MRS protocol at 7T

Young Woo Park1, Dinesh K Deelchand1, James M Joers1, Elizebeth Seaquist2, and Gulin Oz1

1Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Department of Medicine, University of Minnesota, Minneapolis, MN, United States

Studies of neurotransmitter response to changing glycemia levels are needed to address mechanisms of cerebral adaptations to hypoglycemia. Here we present an advanced MRS acquisition protocol that combines commercial 7T hardware, dielectric padding, optical motion tracking and frequency and B0 shim correction to ensure optimal stability of data quality during a challenging infusion protocol to maintain euglycemic and hypoglycemic blood glucose levels. Data obtained from the prefrontal cortex in patients with type 1 diabetes demonstrate excellent quality and reproducibility during euglycemia and hypoglycemia, which will allow robust mechanistic investigations of the primary neurotransmitters, glutamate and GABA, under changing glycemic conditions.

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