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Abstract #2815

GABA and GSH at 7T: to edit or not to edit?

Anouk Marsman1, Anna Lind1, and Esben Thade Petersen1,2

1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2Center for Magnetic Resonance, Dept. Electrical Engineering, Technical University of Denmark, Lyngby, Denmark

With the number of 7T sites increasing, more brain-MRS studies will be conducted at 7T. Particularly GABA and GSH are of interest and benefit from the increased resolution. To date, studies have applied both conventional and edited MRS to measure these metabolites, however, there is no consensus on whether to use edited MRS. This study shows that it depends on brain region and potentially voxel size and number of acquisitions, whether it is preferable to use editing for GABA. There is less reason to argue that editing benefits measurement of GSH, but this study indicates a slight preference for editing.

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