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Abstract #3436

Ex vivo Structural Connectomics of the Mouse Brain Subcortical Regions

Eunbee Kim1 and Hyeon-Man Baek1,2

1GAIST, Incheon, Korea, Republic of, 2Lee Gil Ya Cancer & Diabetes Institute, Incheon, Korea, Republic of

Parkinson's disease (PD) is one of the degenerative brain disease and the hallmark of PD is the death of dopaminergic cells. The subcortical area involved in neuronal circuits which play a central role in the motor control. Structural connectivity can identify abnormal connectivity of neural circuits. Diffusion tensor imaging (DTI) is a non-invasive technique that has been used to delineate the internal anatomy by tracing white matter tracts. In this study, we investigated ex vivo diffusion MR images using perfusion methods and identify the structural connectivity in subcortical regions. In conclusion, we provide structural connectional fingerprints in the mouse model.

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