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Abstract #3499

A novel approach to diffusion phase imaging using non-linear gradients in anisotropic media

Pamela Wochner1, Jason Stockmann2, Torben Schneider3, Jack Lee1, and Ralph Sinkus1

1School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 2Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 3Philips Healthcare UK, Guildford, Surrey, United Kingdom

Classical methods for Diffusion-Weighted MRI use linear gradients to obtain information about tissue microstructure encoded in the loss of MR magnitude. These linear gradients cause diffusing spins to dephase which prevents the use of phase information. When, however, gradient fields are applied that vary quadratically in space, diffusion in anisotropic media results in a shift of net phase with only a minimal loss in signal magnitude enabling the exploration of MR phase. Both the theory of this new concept and Monte-Carlo simulations predict net phase for diffusion experiments using quadratic gradients in anisotropic media in excellent agreement.

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