A custom DW pulse sequence is optimized to minimize echo time and evaluate optimal trade-offs between SNR, b-value and spatial resolution for mapping cortical fiber patterns. Using a lower b-value (500 vs. 1000 s/mm2) failed to improve estimates of the principal fiber orientation in the cortex despite the significant boost in signal. Accurate estimates of the principal fiber orientation in the cortex requires a spatial resolution of 1.44 mm isotropic or less.
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