Abstract #3570

Diffusion of the perivascular space fluid is anisotropic in conventional DWI

Farshid Sepehrband¹, Ryan P Cabeen¹, Jeiran Choupan^1,2, Giuseppe Barisano^1,3,4, Meng Law^1,5, and Arthur W Toga¹

¹Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Psychology, University of Southern California, Los Angeles, CA, United States, ³Neuroscience graduate program, University of Southern California, Los Angeles, CA, United States, ⁴Department of Radiology, University of Southern California, Los Angeles, CA, United States, ⁵Department of Radiology, Alfred Health, Melbourne, Australia

Perivascular space (PVS), also known as Virchow-Robin space, is a pial-lined, fluid-filled structure that surrounds vessels in the cerebral cortex ^1,2, and occupies a large portion of the cerebral tissue. PVS has an anisotropic morphology ^3–5 and is mainly aligned with the white matter ⁶. However, its diffusion MRI profile has not been studied. Here we show experimental evidences that that PVS can be measured with diffusion MRI and the signature of this compartment is anisotropic.

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