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Abstract #3681

Sex-linked neurofunctionnal basis of psychological resilience in late adolescence

Cheng Yang1, Song Wang1, and Qiyong Gong1

1Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, China

Psychological resilience refers to the ability to bounce back from adversity and previous studies have shown sex differences in psychological resilience. Here, we employed amplitude of low-frequency fluctuations (ALFF) to investigate sex differences in the relationship between resting-state brain activity and psychological resilience in 231 healthy adolescents. Behaviorally, we found that males were more resilient than females. Neurally, a positive correlation between psychological resilience and the ALFF in the right orbitofrontal cortex was detected among males while a negative correlation was observed among females. Together, our study provided the first evidence of sex-specific neurofunctional substrates underlining psychological resilience in adolescents.

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