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Abstract #3686

Structural and Resting-State Functional Connectivity Changes of the MPS I Mouse Brain

Wei Zhu1, Yi Zhang1, Yucong Ma2, Kyle Schaible3, Nanyin Zhang2, Xiao-Hong Zhu1, Perry Hackett4, Walter Low3, and Wei Chen1

1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Department of Biomedical Engineering, Penn State University, State College, PA, United States, 3Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States, 4College of Biological Sciences, University of Minnesota, Minneapolis, MN, United States

Mucopolysaccharidoses (MPSs) is a group of inherited lysosomal storage disorders that could cause multiple organ failure, cognitive impairment, and shortened life span. In spite of the recognizable clinical morphological and physiological features associated with MPSs, brain connectivity changes and physiopathologic mechanisms responsible for these alterations in the central nervous system are rarely studied but might be a reliable biomarker for disease severity and treatment efficacy. A new study of brain connectome on MPS I mouse model using resting-state functional MRI (rs-fMRI) technique was conducted and a dramatic deterioration on functional connections involving multiple brain regions were observed.

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