Abstract #3686

Structural and Resting-State Functional Connectivity Changes of the MPS I Mouse Brain

Wei Zhu¹, Yi Zhang¹, Yucong Ma², Kyle Schaible³, Nanyin Zhang², Xiao-Hong Zhu¹, Perry Hackett⁴, Walter Low³, and Wei Chen¹

¹Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Department of Biomedical Engineering, Penn State University, State College, PA, United States, ³Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States, ⁴College of Biological Sciences, University of Minnesota, Minneapolis, MN, United States

Mucopolysaccharidoses (MPSs) is a group of inherited lysosomal storage disorders that could cause multiple organ failure, cognitive impairment, and shortened life span. In spite of the recognizable clinical morphological and physiological features associated with MPSs, brain connectivity changes and physiopathologic mechanisms responsible for these alterations in the central nervous system are rarely studied but might be a reliable biomarker for disease severity and treatment efficacy. A new study of brain connectome on MPS I mouse model using resting-state functional MRI (rs-fMRI) technique was conducted and a dramatic deterioration on functional connections involving multiple brain regions were observed.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.