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Abstract #3687

BOLD-fMRI evaluation of analgesic candidates with different analgesic mechanisms against allodynia-specific pain in a chronic pain animal model

Mikio Sameshima1, Sosuke Yoshinaga1, Naoya Yuzuriha1, Mitsuhiro Takeda1, and Hiroaki Terasawa1

1Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

The aim of this study is to evaluate the pain-relieving effect of a novel chemokine signal-inhibiting compound on allodynia-specific responses in a chronic pain animal model, using our BOLD-fMRI-based pain evaluation system with a green laser. We observed activations in four brain regions related to pain. We found that the compound suppresses green laser-evoked allodynia-specific responses in three regions. We expect that the compound has synergistic pain-relieving effects with existing analgesic agents. Our system is useful to evaluate the effects of new analgesic candidates in non-clinical and, expectantly, clinical studies.

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