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Abstract #3721

Breath-hold BOLD-fMRI cerebrovascular reactivity metrics predict cognitive impairment in cerebral small vessel disease

Joana Pinto1, Tânia Charrua1, Ana Fouto1, Luísa Alves2,3, Sofia Calado2,3, Carina Gonçalves2,3, Margarida Rebolo4, Miguel Viana Baptista2,3, Pedro Vilela5, Rita G Nunes1, and Patrícia Figueiredo1

1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisboa, Portugal, 2Neurology Department, Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal, 3CEDOC - Nova Medical School, New University of Lisbon, Lisboa, Portugal, 4Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, 5Imaging Department, Hospital da Luz, Lisboa, Portugal

Cerebral small vessel disease (SVD) is associated with an increased risk of stroke and dementia, being implicated in age-related cognitive decline. In this work, we investigate the potential of cerebrovascular reactivity (CVR) to provide sensitive biomarkers of SVD, by evaluating metrics extracted from breath-hold BOLD-fMRI in terms of their predictive power of cognitive impairment in a group of SVD patients. We modelled the breath-hold BOLD-fMRI response using a sinusoidal approach, and derived both CVR amplitude and delay-based maps. Multiple linear regression analysis showed that CVR metrics significantly contributed to explain cognitive impairments in working memory, long-term memory and executive function.

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