Abstract #3722

Amplitude of low-frequency fluctuations in resting-state BOLD-fMRI is associated with cognitive decline in cerebral small vessel disease

Joana Moreira¹, Joana Pinto¹, Ana Fouto¹, Luísa Alves^2,3, Sofia Calado^2,3, Carina Gonçalves^2,3, Margarida Rebolo⁴, Pedro Vilela⁵, Miguel Viana Baptista^2,3, and Patrícia Figueiredo¹

¹ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisboa, Portugal, ²Neurology Department, Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal, ³CEDOC - Nova Medical School, New University of Lisbon, Lisboa, Portugal, ⁴Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, ⁵Imaging Department, Hospital da Luz, Lisboa, Portugal

Cerebral small vessel disease (SVD) is a major vascular contributor to dementia and stroke, being associated with age-related cognitive decline. In this work, we aim to assess the potential of spontaneous BOLD fluctuations metrics to predict cognitive impairment in a group of SVD patients, therefore providing sensitive SVD biomarkers. The amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) were computed in four different frequency bands as metrics of spontaneous BOLD signal fluctuations. Results from multiple linear regression analyses demonstrated that spontaneous BOLD fluctuations metrics contribute to the prediction of cognitive impairment in executive function, processing speed and working memory.

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