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Abstract #3722

Amplitude of low-frequency fluctuations in resting-state BOLD-fMRI is associated with cognitive decline in cerebral small vessel disease

Joana Moreira1, Joana Pinto1, Ana Fouto1, Luísa Alves2,3, Sofia Calado2,3, Carina Gonçalves2,3, Margarida Rebolo4, Pedro Vilela5, Miguel Viana Baptista2,3, and Patrícia Figueiredo1

1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisboa, Portugal, 2Neurology Department, Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal, 3CEDOC - Nova Medical School, New University of Lisbon, Lisboa, Portugal, 4Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, 5Imaging Department, Hospital da Luz, Lisboa, Portugal

Cerebral small vessel disease (SVD) is a major vascular contributor to dementia and stroke, being associated with age-related cognitive decline. In this work, we aim to assess the potential of spontaneous BOLD fluctuations metrics to predict cognitive impairment in a group of SVD patients, therefore providing sensitive SVD biomarkers. The amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) were computed in four different frequency bands as metrics of spontaneous BOLD signal fluctuations. Results from multiple linear regression analyses demonstrated that spontaneous BOLD fluctuations metrics contribute to the prediction of cognitive impairment in executive function, processing speed and working memory.

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