Abstract #3723

Voxel-wise analysis of functional MRI activation in regions of provoked impaired cerebrovascular reactivity: a translational model

Marco Piccirelli¹, Christiaan Hendrik Bas van Niftrik¹, Giovanni Muscas¹, Martina Sebök¹, Joseph Arnold Fisher², Oliver Bozinov¹, Antonios Valavanis¹, Luca Regli¹, Christoph Stippich¹, and Jorn Fierstra¹

¹University Hospital Zurich, Zurich, Switzerland, ²University of Toronto, Toronto, ON, Canada

A voxel-wise investigation of the relationship between the cerebrovascular reactivity (BOLD-CVR) alteration and the task-evoked Blood-oxygenation-level dependent functional MRI (BOLD-fMRI) challenges the commonly accepted linear and global correction method used. Our controlled CVR modulation in healthy subjects is a good investigation translational model for patients affected with glioblastomas or stroke.

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