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Abstract #3723

Voxel-wise analysis of functional MRI activation in regions of provoked impaired cerebrovascular reactivity: a translational model

Marco Piccirelli1, Christiaan Hendrik Bas van Niftrik1, Giovanni Muscas1, Martina Sebök1, Joseph Arnold Fisher2, Oliver Bozinov1, Antonios Valavanis1, Luca Regli1, Christoph Stippich1, and Jorn Fierstra1

1University Hospital Zurich, Zurich, Switzerland, 2University of Toronto, Toronto, ON, Canada

A voxel-wise investigation of the relationship between the cerebrovascular reactivity (BOLD-CVR) alteration and the task-evoked Blood-oxygenation-level dependent functional MRI (BOLD-fMRI) challenges the commonly accepted linear and global correction method used. Our controlled CVR modulation in healthy subjects is a good investigation translational model for patients affected with glioblastomas or stroke.

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