Meeting Banner
Abstract #4127

R2* decay rates of hyperpolarized dissolved-phase 129Xe as a novel biomarker of fibrotic lung injury

Jeff Kammerman1, Andrew D Hahn1, and Sean B Fain1

1Medical Physics, University of Wisconsin, Madison, Madison, WI, United States

Spectroscopic imaging of the hyperpolarized xenon-129 dissolved in the pulmonary tissues and blood can probe regional gas exchange within the lung. However, estimates of the frequency shifts and decay rates of the dissolved-phase signal from whole-lung spectroscopy are confounded by the large magnetic field inhomogeneities of the lung. In this work, we develop a regularized, model-based reconstruction that estimates the spectral properties of pulmonary HP 129Xe to improve image quality. Importantly, we show that the estimated r2* decay rates of dissolved-phase compartments differ substantially from those estimated in whole lung spectroscopy and are a significant biomarker of gas-exchange.

This abstract and the presentation materials are available to members only; a login is required.

Join Here