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Abstract #4128

A magnetic susceptibility model of hyperpolarized 129Xe spectroscopy in alveolar tissues

Jeff Kammerman1, Annelise Malkus1, and Sean B Fain1

1Medical Physics, University of Wisconsin, Madison, Madison, WI, United States

Hyperpolarized 129Xe MRI has been used to characterize gas exchange in the lung by measuring xenon dissolved in the red blood cells and pulmonary barrier tissues. However, recent work identified a potential third component of the dissolved-phase spectrum, observed as a splitting of the barrier peak. We propose to explain the appearance of this peak using a signal model that considers the susceptibility differences at the air tissue interface of the alveoli. Integrating this model into whole lung HP 129Xe spectroscopy measures in 8 healthy subjects and 16 patients with idiopathic pulmonary fibrosis, we find improved correlations between the RBC-to-barrier ratio and DLCO %predicted compared to conventional modeling of the dissolved-phase spectrum.

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