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Abstract #4129

Two-site Reproducibility of Hyperpolarized 129Xe MRI Ventilation in Severe Asthma: Implications for Multicenter Clinical Studies

Sarah Svenningsen1,2, Alexei Ouriadov3, Norman B Konyer4, Rachel L Eddy3,5, Andrew R Westcott3,5, David G McCormack6, Melanie Kjarsgaard2, Michael D Noseworthy7, Parameswaran Nair1,2, and Grace Parraga3,5

1Department of Medicine, McMaster University, Hamilton, ON, Canada, 2Firestone Institute for Respiratory Health, St. Joseph’s Healthcare, Hamilton, ON, Canada, 3Robarts Research Institute, Western University, London, ON, Canada, 4Imaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada, 5Department of Medical Biophysics, Western University, London, ON, Canada, 6Department of Medicine, Western University, London, ON, Canada, 7Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada

Despite the demonstrated sensitivity of hyperpolarized 129Xe MRI biomarkers to pulmonary disease onset, progression and treatment response, comparison of findings across sites is challenging as acquisition protocols and procedures are not standardized. To better understand the agreement of hyperpolarized 129Xe MRI ventilation across different clinical sites, severe asthmatics underwent 129Xe MRI at two sites within 24 hours. 129Xe MRI ventilation defect percent was significantly correlated between sites despite inter-site differences in 129Xe polarization, 129Xe volume, gas mixture composition and signal-to-noise ratio. These findings have important implications when generalizing 129Xe MRI data collected at different sites and undertaking multicenter studies.

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