Abstract #4130

Absolute MR thermometry by hyperpolarized 129Xe in UCP1-/- animals reveals UCP1-independent thermogenesis

Michael A Antonacci^1,2, Christian McHugh^1,2, Michele Kelley^1,2, Andrew McCallister^1,2, and Tamara Branca^1,2

¹Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Direct and non-invasive temperature measurements of BAT in UCP1-/- mice could help to settle the debate on whether BAT in UCP1-/- mice is thermogenically competent and whether there exist other UCP1-independent mechanisms for non-shivering thermogenesis. Here we use hyperpolarized xenon MR thermometry for direct absolute temperature measurements of brown adipose tissue in UCP1-/- mice. Hyperpolarized xenon MR thermometry indicates a small but detectable temperature increase in the BAT of UCP1-/- mice after adrenergic stimulation of this tissue.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.