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Abstract #4130

Absolute MR thermometry by hyperpolarized 129Xe in UCP1-/- animals reveals UCP1-independent thermogenesis

Michael A Antonacci1,2, Christian McHugh1,2, Michele Kelley1,2, Andrew McCallister1,2, and Tamara Branca1,2

1Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Direct and non-invasive temperature measurements of BAT in UCP1-/- mice could help to settle the debate on whether BAT in UCP1-/- mice is thermogenically competent and whether there exist other UCP1-independent mechanisms for non-shivering thermogenesis. Here we use hyperpolarized xenon MR thermometry for direct absolute temperature measurements of brown adipose tissue in UCP1-/- mice. Hyperpolarized xenon MR thermometry indicates a small but detectable temperature increase in the BAT of UCP1-/- mice after adrenergic stimulation of this tissue.

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