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Abstract #4132

Measuring Septal Wall Thickness Using Rapid 1D Hyperpolarized Xenon-129 CSSR Acquisitions

Kai Ruppert1, Yi Xin1, Faraz Amzajerdian1, Hooman Hamedani1, Luis Loza1, Tahmina Achekzai1, Ryan J. Baron1, Ian F. Duncan1, Harrilla Profka1, Sarmad Siddiqui1, Mehrdad Pourfathi1, Federico Sertic1, Maurizio F. Cereda2, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Septal wall thickness measurements using hyperpolarized xenon-129 MRI are sensitive to inflammatory or fibrotic pathologies but currently require multi-second breath-holds. We investigated the feasibility of sampling the recovery of the xenon dissolved-phase magnetization in the lung parenchyma in real time using a rapid 1D acquisition technique combined with periodic saturation of the xenon dissolved-phase magnetization, allowing us to extract the septal wall thickness during short breath holds or even in free-breathing rabbits. Our measurements indicate that the correlation between the derived septal wall thickness and the respiratory cycle are low enough to obtain consistent wall-thickness measurements in free-breathing, non-cooperative subjects.

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